Common Use

Zestoretic is a combination medication containing Hydrochlorothiazide and Lisinopril. Hydrochlorothiazide is a thiazide diuretic that prevents the body from absorbing excessive salt, reducing fluid retention. Lisinopril, an ACE inhibitor, lowers blood pressure and alleviates symptoms associated with fluid retention.

Dosage and Direction

Take Zestoretic exactly as prescribed by your doctor. Do not alter the dosage without medical advice. Consume each dose with a glass of water, regardless of meals.

Precautions

• Avoid alcohol consumption.
• Do not use salt substitutes containing potassium.
• Consult your doctor before taking Zestoretic if you have liver or kidney disorders, lupus, asthma, gout, diabetes, congestive heart failure, or are pregnant.
• Regular blood pressure monitoring is necessary while using Zestoretic.

Contraindications

Zestoretic is contraindicated in cases of anuria, hypersensitivity to its components, or a history of angioedema (swelling of the face, extremities, eyes, lips, tongue, or difficulty swallowing or breathing).

Possible Side Effects

Seek immediate medical attention if you experience the following while taking Zestoretic:

• High potassium symptoms: slow heart rate, weak pulse, muscle weakness, tingling.
• Low potassium symptoms: confusion, uneven heart rate, extreme thirst, frequent urination, leg discomfort, muscle weakness.
• Thirst, nausea, vomiting, dry mouth, drowsiness, skin rash, jaundice, reduced urination, swelling, weight gain, or severe allergic reactions (hives, swelling of the face, lips, tongue, or throat).

Drug Interaction

• NSAIDs may reduce the antihypertensive effects of ACE inhibitors.
• Combining Zestoretic with NSAIDs in patients with impaired renal function may worsen kidney function.
• Using Zestoretic with potassium-sparing diuretics can significantly increase serum potassium levels.
• Zestoretic may increase lithium toxicity and interact with cholestyramine and gold injections.

Missed Dose

If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose. Do not double the dose to compensate.

Overdose

If you suspect an overdose and experience nausea, weakness, dizziness, dry mouth, thirst, or muscle pain, seek immediate medical attention.

Storage

Store Zestoretic at room temperature (15-30°C or 59-86°F) in a light-resistant container.

Disclaimer

This information provides general guidance and does not cover all possible directions, drug interactions, or precautions. It is not intended for self-treatment or self-diagnosis. Always consult your healthcare provider for personalized advice. We disclaim responsibility for the accuracy of this information and any consequences of its use or self-treatment.