Generic Tolvaptan
Tolvaptan is primarily used to treat autosomal dominant polycystic kidney disease (adpkd), slowing kidney cyst growth and decline in kidney function. It is effective in managing hyponatremia (low blood sodium levels) by increasing water excretion without losing electrolytes. Tolvaptan works as a vasopressin receptor antagonist, specifically targeting v2 receptors to regulate fluid balance. For adpkd, clinical trials show it delays kidney enlargement and functional deterioration. In hyponatremia, it raises serum sodium concentrations, particularly in cases related to siadh or heart failure. The drug requires careful monitoring due to potential side effects like liver injury or dehydration. Always obtain tolvaptan from a licensed online pharmacy to ensure authenticity and proper dosage.
15 mg
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Tolvaptan
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15 mg
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Tolvaptan
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15 mg
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Tolvaptan
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15 mg
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Tolvaptan
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15 mg
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15 mg
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15 mg
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30 mg
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30 mg
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Tolvaptan
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30 mg
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30 mg
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30 mg
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30 mg
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Tolvaptan
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Product Description
What is Tolvaptan?

Tolvaptan is a selective vasopressin V2-receptor antagonist used to treat hyponatremia and autosomal dominant polycystic kidney disease (ADPKD). It works by blocking the action of vasopressin, which reduces water reabsorption in the kidneys and increases urine output. Tolvaptan helps raise sodium levels in patients with low blood sodium by promoting water excretion. It is also approved to slow kidney function decline in adults with ADPKD. Common side effects include thirst, dry mouth, and frequent urination. Tolvaptan requires careful monitoring due to potential liver toxicity and should be taken under medical supervision.

What is the Active Substance in Tolvaptan?

Tolvaptan's active substance is tolvaptan itself, a selective vasopressin V2 receptor antagonist. It works by blocking the action of vasopressin, reducing water reabsorption in the kidneys. This leads to increased urine production and helps manage conditions like hyponatremia or polycystic kidney disease. Tolvaptan is chemically known as N-[4-[(5R)-7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl]benzoyl]-2-methylbenzamide. It is available in tablet form for oral administration. The drug requires careful dosing to avoid excessive fluid loss or electrolyte imbalances.

What is Tolvaptan Using for?

Tolvaptan is used to treat low blood sodium levels (hyponatremia) by increasing water excretion in urine. It is prescribed for conditions like heart failure, liver cirrhosis, and syndrome of inappropriate antidiuretic hormone secretion (SIADH). The medication works by blocking vasopressin receptors in the kidneys, reducing water retention. It helps balance sodium levels and prevents fluid overload. Tolvaptan is also approved for slowing kidney function decline in autosomal dominant polycystic kidney disease (ADPKD). It should be used under strict medical supervision due to potential side effects.

How Does Tolvaptan Work?

Tolvaptan is a selective vasopressin V2 receptor antagonist that blocks the action of vasopressin in the kidneys. It inhibits the reabsorption of water in the collecting ducts, promoting free water excretion. This leads to increased urine output and reduced urine concentration, helping to manage conditions like hyponatremia. Unlike diuretics, it does not significantly affect electrolyte excretion. Tolvaptan is used to treat hypervolemic or euvolemic hyponatremia in patients with conditions such as heart failure or SIADH. Its effects are dose-dependent and closely monitored to prevent overly rapid sodium correction.

How Should I Take Tolvaptan?

Take tolvaptan exactly as prescribed by your doctor, usually once or twice daily with or without food. Start the dose in the morning to minimize frequent urination at night. Swallow the tablet whole with a glass of water; do not crush or chew it. Avoid grapefruit or grapefruit juice, as it can increase side effects. Stay hydrated but follow your doctor's fluid intake recommendations. Monitor for side effects like thirst, dry mouth, or urine changes and report any severe symptoms.

Is the Tolvaptan Effective?

Tolvaptan is effective in managing conditions like hyponatremia and autosomal dominant polycystic kidney disease (ADPKD). It works by increasing water excretion while retaining sodium, helping to correct low sodium levels. In ADPKD, it slows kidney cyst growth and preserves kidney function over time. Clinical trials have shown its benefits in improving serum sodium levels and delaying disease progression. However, its effectiveness depends on proper patient selection and adherence to dosing guidelines. Potential side effects, like liver toxicity, require monitoring during treatment.

What Kind of Diseases or Dysfunctions is Tolvaptan Effective for?

Tolvaptan is effective for treating hyponatremia, a condition characterized by low sodium levels in the blood. It is specifically used for syndrome of inappropriate antidiuretic hormone secretion (SIADH) and heart failure-related hyponatremia. Tolvaptan is also approved for slowing kidney function decline in adults at risk of rapidly progressing autosomal dominant polycystic kidney disease (ADPKD). It works by blocking vasopressin receptors, promoting water excretion without significant electrolyte loss. The medication is not recommended for correcting acute or life-threatening hyponatremia. Common side effects include thirst, dry mouth, and increased urination.

Tolvaptan Dosage - How Much Should You Take?

The dosage of tolvaptan depends on the condition being treated and individual response. For hyponatremia, the usual starting dose is 15 mg once daily, which may be increased to 30 or 60 mg if needed. For autosomal dominant polycystic kidney disease (ADPKD), the typical dose is 45 mg in the morning and 15 mg in the afternoon. Dosage adjustments may be necessary based on kidney function and tolerability. Always follow your healthcare provider's prescribed dosage and instructions. Taking more than recommended can increase the risk of side effects.

Foods to Avoid When Taking Tolvaptan?

When taking tolvaptan, avoid foods high in sodium, such as processed snacks, canned soups, and fast food, as they can counteract the medication's effects. Steer clear of grapefruit and grapefruit juice, which may increase tolvaptan levels in the blood, raising the risk of side effects. Limit potassium-rich foods like bananas, oranges, and potatoes, as tolvaptan can increase potassium levels. Avoid excessive consumption of alcohol, as it can worsen dehydration or electrolyte imbalances moderated by the drug. Refrain from high-fat meals close to dosing times, as they might slow the absorption of tolvaptan. Minimize caffeine intake, which can contribute to fluid loss and interfere with hydration balance.

How to Order Tolvaptan in Our Online Pharmacy?

To order Tolvaptan from our online pharmacy, first visit our website and search for the medication. Select the desired dosage and quantity, then add it to your cart. Proceed to checkout and enter your shipping details. Choose a payment method and complete the transaction. After payment confirmation, your order will be processed. You'll receive a tracking number once the package is shipped.

Do you have the same prices in your mobile application?

Purchasing Tolvaptan through a mobile app is quick and convenient. Simply download the mobile app now to browse available medications and place your order. The app allows you to compare prices, check dosages, and receive delivery updates. Secure payment options ensure a safe transaction process. Track your order in real-time and get notified upon dispatch. Enjoy a seamless experience with just a few taps on your smartphone.

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